Propane, 1-bromo-3-fluoro- → 5-(2-chloro-4-methoxyphenyl)-3,6-diethyl-N-[4-(3-fluoropropoxy)oxolan-3-yl]pyrazin-2-amine

HRID 809002Notes

Reaction equation

HRID 809002 reaction equation
[Br:58][CH2:59][CH2:60][CH2:61][F:62].[Cl:1][c:2]1[cH:3][c:4]([Cl:5])[cH:6][cH:7][c:8]1-[c:9]1[n:10][c:11]([CH2:12][CH3:13])[c:14]([NH:15][CH:16]2[c:17]3[c:18]([cH:19][cH:20][cH:21][cH:22]3)[CH2:23][CH:24]2[O:25][CH2:26][CH3:27])[n:28][c:29]1[CH2:30][CH3:31].[Cl:32][c:33]1[c:34](-[c:41]2[n:42][c:43]([CH2:56][CH3:57])[c:44]([NH:49][CH:50]3[CH:51]([OH:55])[CH2:52][O:53][CH2:54]3)[n:45][c:46]2[CH2:47][CH3:48])[cH:35][cH:36][c:37]([O:39][CH3:40])[cH:38]1>>[Cl:32][c:33]1[c:34](-[c:41]2[n:42][c:43]([CH2:56][CH3:57])[c:44]([NH:49][CH:50]3[CH:51]([O:55][CH2:59][CH2:60][CH2:61][F:62])[CH2:52][O:53][CH2:54]3)[n:45][c:46]2[CH2:47][CH3:48])[cH:35][cH:36][c:37]([O:39][CH3:40])[cH:38]1

Participants

4

Reactant 3

HCID 67699Propane, 1-bromo-3-fluoro-HCID 221473105-(2,4-dichlorophenyl)-N-(2-ethoxy-2,3-dihydro-1H-inden-1-yl)-3,6-diethylpyrazin-2-amineHCID 235937054-[[5-(2-Chloro-4-methoxyphenyl)-3,6-diethylpyrazin-2-yl]amino]oxolan-3-ol

Product 1

HCID 101273185-(2-chloro-4-methoxyphenyl)-3,6-diethyl-N-[4-(3-fluoropropoxy)oxolan-3-yl]pyrazin-2-amine

Sources & evidence

ORD record
ord-40359581e79640acac1626f7f512c298
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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