Propanal → 1-Propyl-4-{5-[4-(trifluoromethyl)phenyl]pyridin-2-yl}piperazine
Reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:5][CH:4]=1.[CH:23](=O)[CH2:24][CH3:25]>>[CH2:23]([N:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:11]=[CH:10][C:9]([C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:21])[F:22])=[CH:8][CH:7]=3)=[CH:14][N:13]=2)[CH2:16][CH2:17]1)[CH2:24][CH3:25]Participants
3
Procedure
The title compound was prepared by a similar procedure to that described in Example 213, starting from 4-(5-(4-trifluoromethylphenyl)pyridin-2-yl)piperazine and propionaldehyde.
Sources & evidence
- ORD record
- ord-dcf7e7c89cfd4b5c935f1f2575e27db7
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08846677B2
Reaction notes
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