Chloroacetone → 1-{4-[5-(4-Trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}propan-2-one, hydrochloride

HRID 80905Notes

Reaction equation

HRID 80905 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:5][CH:4]=1.[Cl:23][CH2:24][C:25](=[O:27])[CH3:26]>>[ClH:23].[F:22][C:2]([F:1])([F:21])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][N:18]([CH2:24][C:25](=[O:27])[CH3:26])[CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 671450024-(5-(4-Trifluoromethylphenyl)pyridin-2-yl)piperazine

Product 1

HCID 1317307751-{4-[5-(4-Trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}propan-2-one, hydrochloride

Procedure

The title compound was prepared by a similar procedure to that described in Example 55, starting from 4-(5-(4-trifluoromethylphenyl)pyridin-2-yl)piperazine and chloroacetone.

Sources & evidence

ORD record
ord-37d1806cc9bd402da75165b595d291fc
Source dataset
uspto-grants-2014_09
Patent number
US08846677B2

Reaction notes

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