1-Isopropylpiperazine → 4-{2-[4-(Propan-2-yl)piperazin-1-yl]pyrimidin-5-yl}benzonitrile

HRID 80913Notes

Reaction equation

[CH:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].Cl[C:11]1[N:16]=[CH:15][C:14]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=2)=[CH:13][N:12]=1>>[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:11]2[N:12]=[CH:13][C:14]([C:17]3[CH:18]=[CH:19][C:20]([C:21]#[N:22])=[CH:23][CH:24]=3)=[CH:15][N:16]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 780131-Isopropylpiperazine

HCID 86637102HCID 86637102, compound

Product 1

HCID 159514564-{2-[4-(Propan-2-yl)piperazin-1-yl]pyrimidin-5-yl}benzonitrile

Procedure

The title compound was prepared by a similar procedure to that described in Example 1, starting from 1-isopropylpiperazine and 4-(2-chloro-pyrimidin-5-yl)benzonitrile.

Sources & evidence

ORD record: ord-bc48f8264d974cf4b24b802dfee3f9d7
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846677B2

Reaction notes

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