反应详情

To a solution of 2,5-dibromo-4-methyl-pyridine (5.0 g, 20 mmol) and isopropyl-piperazine (25.6 g, 200 mmol) were added pyridine (2.06 g, 206 mmol). The reaction mixture was refluxed for 5 h under a nitrogen atmosphere. Brine was added and the mixture was extracted with EtOAc. The organic extract was washed with brine and 0.5 N hydrochloric acid. The acidic layer was made alkaline with Na2CO3 to pH 8 and then extracted with CH2Cl2. The organic extract was dried (Na2SO4) and concentrated to give 5.4 g (90%) of 1-(5-bromo-4-methyl-pyridin-2-yl)-4-isopropyl-piperazine.

1. temperatureThe reaction mixture was refluxed for 5 h under a nitrogen atmosphere
2. extractionthe mixture was extracted with EtOAc
3. extractionThe organic extract
4. washwas washed with brine and 0.5 N hydrochloric acid
5. extractionextracted with CH2Cl2
6. extractionThe organic extract
7. dry with materialwas dried (Na2SO4)
8. concentrationconcentrated