(2H-1,3-benzodioxol-5-yl)boronic acid → (R)-2-(6-1,3-Benzodioxol-5-ylpyridazin-3-yl)octahydropyrido[1,2-a]pyrazine, dihydrochloride

HRID 80926Notes

Reaction equation

HRID 80926 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]3[CH2:14][CH2:15][CH2:16][CH2:17][C@@H:10]3[CH2:9]2)=[CH:4][CH:3]=1.[CH2:18]1[O:26][C:25]2[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][C:20]=2[O:19]1>>[ClH:1].[ClH:1].[O:19]1[C:20]2[CH:21]=[CH:22][C:23]([C:2]3[N:7]=[N:6][C:5]([N:8]4[CH2:13][CH2:12][N:11]5[CH2:14][CH2:15][CH2:16][CH2:17][C@@H:10]5[CH2:9]4)=[CH:4][CH:3]=3)=[CH:24][C:25]=2[O:26][CH2:18]1

Participants

3

Reactant 2

HCID 2734371(2H-1,3-benzodioxol-5-yl)boronic acidHCID 87285948(r)-2-(6-Chloropyridazin-3-yl)octahydropyrido[1,2-a]pyrazine

Product 1

HCID 131730784(R)-2-(6-1,3-Benzodioxol-5-ylpyridazin-3-yl)octahydropyrido[1,2-a]pyrazine, dihydrochloride

Procedure

The title compound was prepared by a similar procedure to that described in Example 57, starting from (R)-2-(6-chloropyridazin-3-yl)octahydropyrido[1,2-a]pyrazine and 3,4-methylenedioxyphenylboronic acid.

Sources & evidence

ORD record
ord-121edc8d653f4db3852d1db191c1b45f
Source dataset
uspto-grants-2014_09
Patent number
US08846677B2

Reaction notes

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