Acetic Acid → Methyl 3-Amino-3-(1-boc-1,2,3,4-tetrahydro-quinolin-6-yl)-propionate

HRID 809276Notes

Reaction equation

HRID 809276 reaction equation
[CH2:1]([N:8]([CH:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:32]1)[CH3:33])[CH:9]([CH2:10][C:11](=[O:12])[O:13][CH3:14])[c:15]1[cH:16][c:17]2[c:22]([cH:23][cH:24]1)[N:21]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:20][CH2:19][CH2:18]2)[c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[CH3:40][C:41](=[O:42])[OH:43].[CH3:45][CH2:46][OH:47].[OH-:48].[OH-:50].[OH2:44].[Pd+2:49]>>[NH2:8][CH:9]([CH2:10][C:11](=[O:12])[O:13][CH3:14])[c:15]1[cH:16][c:17]2[c:22]([cH:23][cH:24]1)[N:21]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:20][CH2:19][CH2:18]2

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 702EthanolHCID 961Hydroxide2×HCID 962WaterHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 23003960tert-butyl 6-[1-[benzyl(1-phenylethyl)amino]-3-methoxy-3-oxopropyl]-3,4-dihydro-2H-quinoline-1-carboxylate

Product 1

HCID 23003972Methyl 3-Amino-3-(1-boc-1,2,3,4-tetrahydro-quinolin-6-yl)-propionate

Sources & evidence

ORD record
ord-a079c973a7054e3ca421c5e1576e8f38
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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