Boronic Acid → (4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(4-trifluoromethoxy-phenyl)-1H-indol-2-yl]-methanone

HRID 809300Notes

Reaction equation

HRID 809300 reaction equation
[BH:30]([OH:31])[OH:32].[F:1][C:2]1([F:29])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[c:10]2[nH:11][c:12]3[cH:13][cH:14][c:15]([O:19][CH:20]4[CH2:21][CH2:22][N:23]([CH:26]([CH3:27])[CH3:28])[CH2:24][CH2:25]4)[cH:16][c:17]3[cH:18]2)[CH2:6][CH2:7]1.[F:33][C:34]([O:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1)([F:42])[F:43]>>[F:1][C:2]1([F:29])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[c:10]2[n:11](-[c:39]3[cH:38][cH:37][c:36]([O:35][C:34]([F:33])([F:42])[F:43])[cH:41][cH:40]3)[c:12]3[cH:13][cH:14][c:15]([O:19][CH:20]4[CH2:21][CH2:22][N:23]([CH:26]([CH3:27])[CH3:28])[CH2:24][CH2:25]4)[cH:16][c:17]3[cH:18]2)[CH2:6][CH2:7]1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 68010(Trifluoromethoxy)benzeneHCID 11603838(4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone

Product 1

HCID 16739415(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(4-trifluoromethoxy-phenyl)-1H-indol-2-yl]-methanone

Sources & evidence

ORD record
ord-0aa62f10c8ff48eca949a1d427b99b00
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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