1-(2-Bromoethoxy)-4-fluorobenzene → 1-[2-(4-Fluorophenyl)oxyethyl]-4-(4-phenoxyphenyl)piperidine
Reaction equation
[F:20][c:21]1[cH:22][cH:23][c:24]([O:27][CH2:28][CH2:29][Br:30])[cH:25][cH:26]1.[O:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][cH:10][c:11]([CH:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[cH:12][cH:13]1>>[O:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][cH:10][c:11]([CH:14]2[CH2:15][CH2:16][N:17]([CH2:29][CH2:28][O:27][c:24]3[cH:23][cH:22][c:21]([F:20])[cH:26][cH:25]3)[CH2:18][CH2:19]2)[cH:12][cH:13]1Participants
3
Sources & evidence
- ORD record
- ord-25c2e9451594400a858ac346bed24eec
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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