1,4-Dioxane → [6-[4-[4-bromo-6-(trifluoromethyl)-1H-benzimidazol-2-yl]-3-methylpiperazin-1-yl]-5-chloro-3-pyridinyl]methanol

HRID 809348Notes

Reaction equation

HRID 809348 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:12]([F:13])([F:14])[F:15])[cH:5][c:6]2[c:7]1[nH:8][c:9]([Cl:11])[n:10]2.[Cl:16][c:17]1[cH:18][c:19]([CH2:30][OH:31])[cH:20][n:21][c:22]1[N:23]1[CH2:24][CH:25]([CH3:29])[NH:26][CH2:27][CH2:28]1.[O:32]1[CH2:33][CH2:34][O:35][CH2:36][CH2:37]1>>[Br:1][c:2]1[cH:3][c:4]([C:12]([F:13])([F:14])[F:15])[cH:5][c:6]2[c:7]1[nH:8][c:9]([N:26]1[CH:25]([CH3:29])[CH2:24][N:23]([c:22]3[c:17]([Cl:16])[cH:18][c:19]([CH2:30][OH:31])[cH:20][n:21]3)[CH2:28][CH2:27]1)[n:10]2

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 69216273[5-Chloro-6-(3-methylpiperazin-1-yl)-3-pyridinyl]methanolHCID 178506061HCID 178506061, compound

Product 1

HCID 178430125[6-[4-[4-bromo-6-(trifluoromethyl)-1H-benzimidazol-2-yl]-3-methylpiperazin-1-yl]-5-chloro-3-pyridinyl]methanol

Sources & evidence

ORD record
ord-07a06ae806574a888e20df7e92867d19
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…