反应详情

温度

100 °C

L-Tryptophane (5 g; 24.5 mmol) and thionyl chloride (73.5 mmol; 5.3 ml) were dissolved in n-butanol (80 ml) and stirred at 100° C. over night. The product 5 precipitated after cooling to room temperature, was filtered off and washed with ice cold butanol and petrol ether. The product was dried at the oil pump, yielding 5.8 g of 5 (91%).

1. customThe product 5 precipitated
2. temperatureafter cooling to room temperature
3. filtrationwas filtered off
4. washwashed with ice cold butanol and petrol ether
5. customThe product was dried at the oil pump