Phenylboronic Acid → 2-Chloro-4-(4-phenoxyphenyl)nicotinonitrile

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Reaction Steps

Following conditions described in Step 1 of Example 3, 2-chloro-4-(4-hydroxyphenyl)nicotinonitrile was reacted with phenylboronic acid to give 2-chloro-4-(4-phenoxyphenyl)nicotinonitrile (60 mg, 90% yield). 1H NMR (500 MHz, CDCl3) 8 ppm 8.56 (1H, δ, J=5.22 Hz), 7.53-7.67 (2H, m), 7.37-7.49 (3H, m), 7.22 (1H, t, J=7.42 Hz), 7.09-7.16 (4H, m); MS (ES+) m/z: 307 (M+H); LC retention time: 3.863 min (analytical HPLC Method A).

Provenance & Evidence