Methanol → 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-5-chlorobenzoic acid

HRID 810362Notes

Reaction equation

HRID 810362 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([C:21]#[N:22])[cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH3:25][OH:26].[Na+:24].[OH-:23]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([C:21](=[O:23])[OH:26])[cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 667578634-(4-Chloro-2-cyano-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 665995652-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-5-chlorobenzoic acid

Sources & evidence

ORD record
ord-a2e596566d3e4049a46c4856587d0057
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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