Thionyl Chloride → Lercanidipine Impurity 5

HRID 810557Notes

Reaction equation

HRID 810557 reaction equation
[CH3:1][C:2]1=[C:7]([C:8](=[O:9])[O:10][CH3:11])[CH:6]([c:12]2[cH:13][c:14]([N+:18](=[O:19])[O-:20])[cH:15][cH:16][cH:17]2)[C:5]([C:21](=[O:22])[OH:23])=[C:4]([CH3:24])[NH:3]1.[S:25]([Cl:26])([Cl:27])=[O:28]>>[CH3:1][C:2]1=[C:7]([C:8](=[O:9])[O:10][CH3:11])[CH:6]([c:12]2[cH:13][c:14]([N+:18](=[O:19])[O-:20])[cH:15][cH:16][cH:17]2)[C:5]([C:21](=[O:22])[Cl:27])=[C:4]([CH3:24])[NH:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 1733222,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester

Product 1

HCID 13317254Lercanidipine Impurity 5

Sources & evidence

ORD record
ord-c39b960fe261451182de2e3c42152fbe
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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