Dichloromethane → tert-Butyl 4-(2-(4-(2-fluoro-4-(3-(2-(4-fluorophenyl)acetyl)ureido)phenoxy)pyridin-3-yl)ethynyl)cyclohex-3-enylcarbamate
Reaction equation
[Cl:45][CH2:46][Cl:47].[F:32][c:33]1[cH:34][cH:35][c:36]([CH2:39][C:40](=[O:41])[N:42]=[C:43]=[O:44])[cH:37][cH:38]1.[NH2:1][c:2]1[cH:3][c:4]([F:31])[c:5]([O:6][c:7]2[c:8]([C:13]#[C:14][C:15]3=[CH:16][CH2:17][CH:18]([NH:21][C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:19][CH2:20]3)[cH:9][n:10][cH:11][cH:12]2)[cH:29][cH:30]1>>[NH:1]([c:2]1[cH:3][c:4]([F:31])[c:5]([O:6][c:7]2[c:8]([C:13]#[C:14][C:15]3=[CH:16][CH2:17][CH:18]([NH:21][C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:19][CH2:20]3)[cH:9][n:10][cH:11][cH:12]2)[cH:29][cH:30]1)[C:43]([NH:42][C:40]([CH2:39][c:36]1[cH:35][cH:34][c:33]([F:32])[cH:38][cH:37]1)=[O:41])=[O:44]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-a101ac09f4e6488982f2abd9b4f8da1b
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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