HRID81075
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
The acid from Step 2 of Example 248 and dimethylamine were coupled with HATU and subsequently reacted with hydrazine following conditions in Step 3 of Example 248 to give Example 249. 1H NMR (400 MHz, methanol-d4) δ ppm 7.91-7.97 (2H, m), 7.65 (1H, d, J=2.51 Hz), 7.47-7.54 (2H, m), 7.31 (1H, t, J=7.40 Hz), 7.18-7.24 (4H, m), 6.78 (1H, s), 6.05 (1H, d, J=2.26 Hz), 5.09 (2H, s), 3.03 (3H, s), 2.86 (3H, s); MS (ES+) m/z: 469.5 (M+H); LC retention time: 3.238 min (analytical HPLC
WORKUP
后处理
- customto give Example 249