Ethanol → Ethyl 3-(1-azetidin-3-yl-2-fluoro-2-methylpropyl)-5-fluorobenzoate

HRID 810810Notes

Reaction equation

HRID 810810 reaction equation
[CH3:37][CH2:38][OH:39].[H:35][H:36].[OH-:40].[OH-:41].[Pd+2:42].[c:1]1([CH:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:29]2)[N:8]2[CH2:9][CH:10]([CH:12]([C:13]([CH3:14])([CH3:15])[F:16])[c:17]3[cH:18][c:19]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[cH:25][c:26]([F:28])[cH:27]3)[CH2:11]2)[cH:30][cH:31][cH:32][cH:33][cH:34]1>>[NH:8]1[CH2:9][CH:10]([CH:12]([C:13]([CH3:14])([CH3:15])[F:16])[c:17]2[cH:18][c:19]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[cH:25][c:26]([F:28])[cH:27]2)[CH2:11]1

Participants

6

Reactant 5

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 67055389Ethyl 3-{1-[1-(diphenylmethyl)azetidin-3-yl]-2-fluoro-2-methylpropyl}-5-fluorobenzoateHCID 178418361HCID 178418361, compound

Product 1

HCID 67055353Ethyl 3-(1-azetidin-3-yl-2-fluoro-2-methylpropyl)-5-fluorobenzoate

Sources & evidence

ORD record
ord-e05c55402080458c99182ee23feb7479
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…