HCID 178452762, compound → HCID 178461256, compound

HRID 81095Notes

Reaction equation

HRID 81095 reaction equation
[Cl:1][C:2]1[C:7]([NH:8][CH2:9][C@H:10]2[CH2:15][CH2:14][C@H:13]([CH3:16])[CH2:12][CH2:11]2)=[C:6]([NH:17]C(=O)OC(C)(C)C)[CH:5]=[C:4]([Cl:25])[N:3]=1>Cl.O1CCOCC1>[Cl:1][C:2]1[C:7]([NH:8][CH2:9][C@H:10]2[CH2:11][CH2:12][C@H:13]([CH3:16])[CH2:14][CH2:15]2)=[C:6]([NH2:17])[CH:5]=[C:4]([Cl:25])[N:3]=1

Participants

3

Reactant 1

HCID 178452762HCID 178452762, compound

Product 1

HCID 178461256HCID 178461256, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A solution of tert-butyl (2,6-dichloro-3-(((trans-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate (150 g, 0.386 mol) in HCl/1,4-dioxane (4 M, 3.0 L) was stirred at 45° C. for 15 h. The mixture was concentrated under reduced pressure to give crude 2,6-dichloro-N3-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-413b870ead814d5fb8d61fbeb02e00b3
Source dataset
uspto-grants-2014_09
Patent number
US08846657B2

Reaction notes

Loading…