2,4-Bis(trifluoromethyl)benzoic acid → N-(2-pyrrolidin-1-ylcyclopentyl)-2,4-bis(trifluoromethyl)benzamide

HRID 811256Notes

Reaction equation

HRID 811256 reaction equation
[F:12][C:13]([c:14]1[c:15]([C:16](=[O:17])[OH:18])[cH:19][cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[cH:22]1)([F:27])[F:28].[N:1]1([CH:6]2[CH:7]([NH2:11])[CH2:8][CH2:9][CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5]1>>[N:1]1([CH:6]2[CH:7]([NH:11][C:16]([c:15]3[c:14]([C:13]([F:12])([F:27])[F:28])[cH:22][c:21]([C:23]([F:24])([F:25])[F:26])[cH:20][cH:19]3)=[O:17])[CH2:8][CH2:9][CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 1417522,4-Bis(trifluoromethyl)benzoic acidHCID 167924612-(Pyrrolidin-1-yl)cyclopentan-1-amine

Product 1

HCID 51001077N-(2-pyrrolidin-1-ylcyclopentyl)-2,4-bis(trifluoromethyl)benzamide

Sources & evidence

ORD record
ord-d4d37b6fa5b847e08eed1184136bed8c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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