HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylate → 4-Methoxy-2-(1-methoxycyclopropyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylate | HCID 86724494 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Methoxy-2-(1-methoxycyclopropyl)pyrrolidine | HCID 86724495 | — |
Reaction Steps
To benzyl 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine-1-carboxylate (141 mg, 0.462 mmol) dissolved in ethyl acetate (3.1 mL) was added palladium on carbon (49.1 mg, 0.05 mmol). Hydrogen gas was added via balloon and the reaction was stirred at room temperature for 3 hours. The mixture was filtered over celite and concentrated under reduced pressure to afford 4-methoxy-2-(1-methoxycyclopropyl)pyrrolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846657B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-42d9d219fb804727a47f3f298fb60684 |
| Source note | uspto-grants-2014_09 |