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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 811364Generated: October 30, 2026

Tetrahydrofuran → 2-Fluoro-4(2,2,4,4-tetramethyl-chroman-6yl-ethynyl)-benzoic acid methyl ester

https://huagongshe.com/reaction/811364

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantHexaneHCID 8058—
ReactantTriethylamineHCID 8471—
ReactantEthyl AcetateHCID 8857—
ReactantTriphenylphosphineHCID 11776—
ReactantPalladium ChlorideHCID 24290—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
Reactant2,2,4,4-Tetramethyl-6-ethynylchromanHCID 15661138—
ReactantMethyl 2-fluoro-4-iodobenzoateHCID 22568800—
Product2-Fluoro-4(2,2,4,4-tetramethyl-chroman-6yl-ethynyl)-benzoic acid methyl esterHCID 69548883—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-61e649b4265746629d02325028737b71
Source noteTest data from https://doi.org/10.1039/C8SC04228D