Hydrochloric Acid → rac-(3R,6R)-6-methylpiperidin-3-ol hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-methylpyridin-3-ol (20.0 g, 0.183 mol) in MeOH (200 mL) were added concentrated HCl (15.43 mL, 0.1850 mol) and PtO2 (2.40 g, 0.011 mol). The resulting mixture was heated to 70° C. at 50 PSI overnight. The reaction was filtered to remove the PtO2 and concentrated to a solid to provide ±trans-6-methylpiperidin-3-ol hydrochloride. The crude solid was taken on without further purification.

Provenance & Evidence