反应详情

温度

80 °C

To a stirred solution of 6-benzyl-2,2-difluoro-6-azabicyclo[3.1.0]hexane (25 mg, 0.11 mmol) in CH3CN (1 mL), acetic acid (1 mL) was added at room temperature. The reaction mixture was heated to 80° C. for 16 h, cooled to room temperature and concentrated in vacuo. Purification of the residue on a silica gel column with 0 to 20% EtOAc/Hexanes afforded trans-2-(benzylamino)-3,3-difluorocyclopentyl acetate. MS ESI calc'd. for C14H17F2NO2 [M+H]+ 270. found 270.

1. temperaturecooled to room temperature
2. concentrationconcentrated in vacuo
3. customPurification of the residue on a silica gel column with 0 to 20% EtOAc/Hexanes