2,2'-Bis(dicyclohexylphosphino)-1,1'-biphenyl → 1-(4-{3-[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperazin-1-yl)-2-methyl-propan-2-ol

HRID 811792Notes

Reaction equation

HRID 811792 reaction equation
[CH:39]1([P:40]([CH:41]2[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46]2)[c:47]2[cH:48][cH:49][cH:50][cH:51][c:52]2-[c:53]2[cH:54][cH:55][cH:56][cH:57][c:58]2[P:59]([CH:60]2[CH2:61][CH2:62][CH2:63][CH2:64][CH2:65]2)[CH:66]2[CH2:67][CH2:68][CH2:69][CH2:70][CH2:71]2)[CH2:72][CH2:73][CH2:74][CH2:75][CH2:76]1.[Cl:1][c:2]1[n:3][n:4]2[c:5]([c:6](-[c:10]3[cH:11][cH:12][c:13]([S:16](=[O:17])(=[O:18])[CH3:19])[cH:14][cH:15]3)[cH:7][cH:8][cH:9]2)[n:20]1.[NH2:21][c:22]1[cH:23][c:24]([N:28]2[CH2:29][CH2:30][N:31]([CH2:34][C:35]([CH3:36])([OH:37])[CH3:38])[CH2:32][CH2:33]2)[cH:25][cH:26][cH:27]1>>[c:2]1([NH:21][c:22]2[cH:23][c:24]([N:28]3[CH2:29][CH2:30][N:31]([CH2:34][C:35]([CH3:36])([OH:37])[CH3:38])[CH2:32][CH2:33]3)[cH:25][cH:26][cH:27]2)[n:3][n:4]2[c:5]([c:6](-[c:10]3[cH:11][cH:12][c:13]([S:16](=[O:17])(=[O:18])[CH3:19])[cH:14][cH:15]3)[cH:7][cH:8][cH:9]2)[n:20]1

Participants

4

Reactant 3

HCID 249469872,2'-Bis(dicyclohexylphosphino)-1,1'-biphenylHCID 580713221-[4-(3-Amino-phenyl)-piperazin-1-yl]-2-methyl-propan-2-olHCID 674814372-Chloro-8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 498383891-(4-{3-[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperazin-1-yl)-2-methyl-propan-2-ol

Sources & evidence

ORD record
ord-ff2e0bb97a7145369cc52384ef134bb4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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