HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 8118Generated: October 26, 2026
Nitroethane → 6-fluoro-5-methoxy-3-(2-nitro-propenyl)-1H-indole
https://huagongshe.com/reaction/8118
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitroethane | HCID 6587 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 6-fluoro-5-methoxy-1H-indole-3-carbaldehyde | HCID 22014804 | — |
| Product | 6-fluoro-5-methoxy-3-(2-nitro-propenyl)-1H-indole | HCID 69516792 | 92% |
Reaction Steps
A mixture of nitroethane(44 ml, 611 mmol), 6-fluoro-5-methoxy-1H-indole-3-carbaldehyde (11.8 g, 61 mmol), and ammonium acetate(1.78 g, 23 mmol) is stirred at 100° C. for 3 hours, allowed to cool, and is filtered to give 14 g of 6-fluoro-5-methoxy-3-(2-nitro-propenyl)-1H-indole (92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07087635B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-a2dc7544472245ceae1897b7f180e6d7 |
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| Source note | uspto-grants-2006_08 |
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