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HRID81184

反应详情

EQUATION

反应方程式

HRID 81184 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)[C@@H]1CCCN1
HCID145742

L-Proline

C5H9NO2

结构：C[C@H]1CC[C@H](Cn2c(Br)nc3cc(C#N)nc(-c4cncc(Cl)c4)c32)CC1
HCID178461197

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1CC[C@H](Cn2c(N3CCC[C@H]3C(=O)O)nc3cc(C#N)nc(-c4cncc(Cl)c4)c32)CC1
HCID178461212

未命名化合物

PROCEDURE

实验过程

(S)-1-(4-(5-chloropyridin-3-yl)-6-cyano-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridin-2-yl)pyrrolidine-2-carboxylic acid was prepared using a procedure analogous to that described in Example 3.94 (Step 1) using 2-bromo-4-(5-chloropyridin-3-yl)-3-((trans-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile (Preparative Example 3.1) and L-proline. MS ESI calc'd. for C25H27ClN6O2 [M+H]+ 479. found 479.