4-Hydroxypyrrolidine → 1-[3-Fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-ol
Reaction equation
[Br:1][c:2]1[c:3]([C:9]([F:10])([F:11])[F:12])[c:4]([F:8])[cH:5][cH:6][cH:7]1.[OH:13][CH:14]1[CH2:15][NH:16][CH2:17][CH2:18]1>>[c:2]1([N:16]2[CH2:15][CH:14]([OH:13])[CH2:18][CH2:17]2)[c:3]([C:9]([F:10])([F:11])[F:12])[c:4]([F:8])[cH:5][cH:6][cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-987b081f20134486be7bdb4b7377be53
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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