Acetonitrile → [4-(2-Azepan-1-yl-ethoxy)-phenyl]-[6-methoxy-2-(2,3,5-trifluorophenyl)-naphthalen-1-yl]-methanone

HRID 812702Notes

Reaction equation

HRID 812702 reaction equation
[Br:41][c:42]1[c:43]([F:50])[c:44]([F:49])[cH:45][c:46]([F:48])[cH:47]1.[CH3:52][C:53]#[N:54].[Cs+:40].[F-:39].[N:1]1([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][c:14]([C:15](=[O:16])[c:17]3[c:18]([O:29][S:30]([C:31]([F:32])([F:33])[F:34])(=[O:35])=[O:36])[cH:19][cH:20][c:21]4[cH:22][c:23]([O:27][CH3:28])[cH:24][cH:25][c:26]34)[cH:37][cH:38]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[Pd:51]>>[N:1]1([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][c:14]([C:15](=[O:16])[c:17]3[c:18](-[c:42]4[c:43]([F:50])[c:44]([F:49])[cH:45][c:46]([F:48])[cH:47]4)[cH:19][cH:20][c:21]4[cH:22][c:23]([O:27][CH3:28])[cH:24][cH:25][c:26]34)[cH:37][cH:38]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

7

Reactant 6

HCID 6342AcetonitrileHCID 23938PalladiumHCID 28179Fluoride IonHCID 104967Cesium cationHCID 27363991-Bromo-2,3,5-trifluorobenzeneHCID 57552509Trifluoromethanesulfonic acid 1-[4-(2-azepan-1-yl-ethoxy)-benzoyl]-6-methoxynaphthalen-2-yl ester

Product 1

HCID 57552540[4-(2-Azepan-1-yl-ethoxy)-phenyl]-[6-methoxy-2-(2,3,5-trifluorophenyl)-naphthalen-1-yl]-methanone

Sources & evidence

ORD record
ord-76a95cb06f14465c931dfda6e7caeb5c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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