Dichloromethane → N-[2-(4-Aminomethyl-6-chloro-2H-benzotriazol-2-yl)-1-cyano-1-methylethyl]-4-trifluoromethoxybenzamide

HRID 813258Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][CH2:8][c:9]1[cH:10][c:11]([Cl:37])[cH:12][c:13]2[n:14][n:15]([CH2:18][C:19]([NH:20][C:21]([c:22]3[cH:23][cH:24][c:25]([O:28][C:29]([F:30])([F:31])[F:32])[cH:26][cH:27]3)=[O:33])([CH3:34])[C:35]#[N:36])[n:16][c:17]12)([CH3:5])([CH3:6])[CH3:38].[CH3:39][Si:40]([I:41])([CH3:42])[CH3:43].[Cl:44][CH2:45][Cl:46]>>[NH2:7][CH2:8][c:9]1[cH:10][c:11]([Cl:37])[cH:12][c:13]2[n:14][n:15]([CH2:18][C:19]([NH:20][C:21]([c:22]3[cH:23][cH:24][c:25]([O:28][C:29]([F:30])([F:31])[F:32])[cH:26][cH:27]3)=[O:33])([CH3:34])[C:35]#[N:36])[n:16][c:17]12

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 85247Trimethylsilyl iodide

HCID 66621023{6-chloro-2-[2-cyano-2-methyl-2-(4-trifluoromethoxy-benzoylamino)-ethyl]-2H-benzotriazol-4-ylmethyl}-carbamic acid tert-butyl ester

Product 1

HCID 66620415N-[2-(4-Aminomethyl-6-chloro-2H-benzotriazol-2-yl)-1-cyano-1-methylethyl]-4-trifluoromethoxybenzamide

Sources & evidence

ORD record: ord-35d0b53f36c543f2bdb58321871d5c6e
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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