4-Amino-2,2,6,6-tetramethylpiperidine → N-(3-{8-(2,6-difluorophenyl)-7-oxo-2-[(2,2,6,6-tetramethyl-4-piperidinyl)amino]-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl}-4-methylphenyl)-2-thiophenecarboxamide

HRID 813349Notes

Reaction equation

HRID 813349 reaction equation
[CH3:39][C:40]1([CH3:49])[NH:41][C:42]([CH3:47])([CH3:48])[CH2:43][CH:44]([NH2:46])[CH2:45]1.[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:38])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([S:34]([CH3:35])(=[O:36])=[O:37])[n:17][c:18]3-[c:19]2[cH:20][c:21]([NH:26][C:27](=[O:28])[c:29]3[s:30][cH:31][cH:32][cH:33]3)[cH:22][cH:23][c:24]2[CH3:25])[c:4]([F:8])[cH:5][cH:6][cH:7]1>>[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:38])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([NH:46][CH:44]2[CH2:43][C:42]([CH3:47])([CH3:48])[NH:41][C:40]([CH3:39])([CH3:49])[CH2:45]2)[n:17][c:18]3-[c:19]2[cH:20][c:21]([NH:26][C:27](=[O:28])[c:29]3[s:30][cH:31][cH:32][cH:33]3)[cH:22][cH:23][c:24]2[CH3:25])[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 375244-Amino-2,2,6,6-tetramethylpiperidineHCID 11947856N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-2-thiophenecarboxamide

Product 1

HCID 11948276N-(3-{8-(2,6-difluorophenyl)-7-oxo-2-[(2,2,6,6-tetramethyl-4-piperidinyl)amino]-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl}-4-methylphenyl)-2-thiophenecarboxamide

Sources & evidence

ORD record
ord-8b32576d62d843d5a8498600df487cf9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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