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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 813373Generated: October 30, 2026

Toluene → 5-Chloro-N-{2-[3-(cyanomethoxy)benzyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-2-thiophenecarboxamide

https://huagongshe.com/reaction/813373

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
ReactantTetrahydrofuranHCID 8028—
ReactantEthyl AcetateHCID 8857—
ReactantTriphenylphosphineHCID 11776—
Reactantethyl N-ethoxycarbonyliminocarbamateHCID 220568—
Reactant5-Chloro-N-(1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)thiophene-2-carboxamideHCID 4135740—
Reactant2-[3-(Hydroxymethyl)phenoxy]acetonitrileHCID 11321137—
Product5-Chloro-N-{2-[3-(cyanomethoxy)benzyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-2-thiophenecarboxamideHCID 9955496—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-73fd2c26fd04422eb41efef0d2f86a21
Source noteTest data from https://doi.org/10.1039/C8SC04228D