反应详情

温度

-78 °C

7-methoxy-2,3,3-trimethyl-2,3-dihydro-isoindol-1-one (0.18 g) is dissolved in CH2Cl2 (4.5 mL) and cooled to −78° C. After the addition of BBr3 (1 molar in CH2Cl2, 2.92 mL) the reaction mixture is allowed to warm up to −10° C. within 3 h. For working up it is diluted with CH2Cl2 and extracted with NaCl solution (H2O, 10%). The organic phase is dried on magnesium sulphate, filtered off from the desiccant and the solvent is eliminated in vacuo. The residue is used in the next reaction step without any further purification.

1. temperatureto warm up to −10° C. within 3 h
2. extractionextracted with NaCl solution (H2O, 10%)
3. customThe organic phase is dried on magnesium sulphate
4. filtrationfiltered off from the desiccant and the solvent
5. customThe residue is used in the next reaction step without any further purification