3-({5-[5-(4-Isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrazin-2-ylmethyl}-amino)-cis-cyclobutanecarboxylic acid → 3-({5-[5-(4-Isobutyl-phenyl)-[1,3,4]oxadiazol-2-yl]-pyridin-2-ylmethyl}-amino)-cis-cyclobutanecarboxylic acid

HRID 813581Notes

Reaction equation

HRID 813581 reaction equation
[CH2:23]([c:24]1[cH:25][cH:26][c:27](-[c:28]2[o:29][n:30][c:31](-[c:32]3[cH:33][cH:34][c:35]([CH:36]=[O:37])[n:38][cH:39]3)[n:40]2)[cH:41][cH:42]1)[CH:43]([CH3:44])[CH3:45].[CH2:46]([c:47]1[cH:48][cH:49][c:50](-[c:51]2[o:52][n:53][c:54](-[c:55]3[n:56][cH:57][c:58]([CH2:67][NH:68][CH:69]4[CH2:70][CH:71]([C:73](=[O:74])[OH:75])[CH2:72]4)[n:59][cH:60]3)[n:61]2)[cH:62][cH:63]1)[CH:64]([CH3:65])[CH3:66].[Cl:1][c:2]1[n:3][cH:4][c:5](-[c:8]2[o:9][c:10](-[c:13]3[cH:14][cH:15][c:16]([CH2:19][CH:20]([CH3:21])[CH3:22])[cH:17][cH:18]3)[n:11][n:12]2)[cH:6][cH:7]1>>[c:2]1([CH2:67][NH:68][CH:69]2[CH2:70][CH:71]([C:73](=[O:74])[OH:75])[CH2:72]2)[n:3][cH:4][c:5](-[c:8]2[o:9][c:10](-[c:13]3[cH:14][cH:15][c:16]([CH2:19][CH:20]([CH3:21])[CH3:22])[cH:17][cH:18]3)[n:11][n:12]2)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 177573723-({5-[5-(4-Isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrazin-2-ylmethyl}-amino)-cis-cyclobutanecarboxylic acidHCID 592042725-[5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl]pyridine-2-carbaldehydeHCID 592042812-Chloro-5-[5-(4-isobutylphenyl)-1,3,4-oxadiazol-2-yl]pyridine

Product 1

HCID 248954753-({5-[5-(4-Isobutyl-phenyl)-[1,3,4]oxadiazol-2-yl]-pyridin-2-ylmethyl}-amino)-cis-cyclobutanecarboxylic acid

Sources & evidence

ORD record
ord-871eece2bfd54d8a9ffa930b29259b0d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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