HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 81393Generated: October 30, 2026
Triethylamine → HCID 58483968, compound
https://huagongshe.com/reaction/81393
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | tert-Butyl (2R,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 58483823 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58483968 | HCID 58483968 | — |
Reaction Steps
7.5 3.2 g of tert-butyl (2R,4S)-4-fluoro-2-hydroxymethylpyrrolidine-1-carboxylate are dissolved in 50 ml of CH2Cl2 with stirring, 3.1 ml of triethylamine are added, the mixture is cooled to 0-5° C., and a solution of 1.4 ml of methane-sulfonyl chloride in 10 ml of CH2Cl2 is subsequently added dropwise. The mixture is subsequently stirred at RT for 4 h. After aqueous work-up, the 4.1 g of tert-butyl (2R,4S)-4-fluoro-2-methanesulfonyloxymethylpyrrolidine-1-carboxylate) obtained are reacted further directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08846694B2 |
|---|
| Source dataset | uspto-grants-2014_09 |
|---|
| ORD ID | ord-983190d0194e4829bd268b898157d838 |
|---|
| Source note | uspto-grants-2014_09 |
|---|
