Hydrochloric Acid → (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine

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Reaction Steps

7.7 2.5 g of tert-butyl (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine-1-carboxylate are dissolved in 20 ml of THF and stirred at 80° C. for 2 h with 5 ml of ethanolic hydrochloric acid. After basic work-up using saturated sodium hydrogencarbonate solution, the organic phase is subjected to conventional work-up, and the residue obtained is purified by chromatography, giving 780 mg of (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine as brown oil; Rt.: 0.700 min; [M+H]+230.2.

Provenance & Evidence