HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-((R)-1-pyrrolidin-2-ylmethoxy)-3,4-dihydro-2H-naphthalen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 67445985 | HCID 67445985 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 5-((R)-1-pyrrolidin-2-ylmethoxy)-3,4-dihydro-2H-naphthalen-1-one | HCID 58483931 | — |
Reaction Steps
13.2 6.5 g of tert-butyl (R)-2-(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yloxy-methyl)pyrrolidine-1-carboxylate are reacted with trifluoroacetic acid in dichloroethane and worked up as described, giving 4.1 g of 5-((R)-1-pyrrolidin-2-ylmethoxy)-3,4-dihydro-2H-naphthalen-1-one; Rt.: 1.325 min; [M-1-H]+246.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846694B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-aeb871ddbd31448daba4baf2f0f3c2d4 |
| Source note | uspto-grants-2014_09 |