1-(Methylsulfonyl)piperazine → 1-(5-Tert-butylisoxazol-3-yl)-3-(3-(7-methoxy-6-(2-(4-(methylsulfonyl)piperazin-1-yl)ethoxy)quinazolin-4-ylthio)phenyl)urea
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([NH:10][C:11](=[O:12])[NH:13][c:14]2[cH:15][c:16]([S:20][c:21]3[n:22][cH:23][n:24][c:25]4[cH:26][c:27]([O:35][CH3:36])[c:28]([O:31][CH2:32][CH2:33][Cl:34])[cH:29][c:30]34)[cH:17][cH:18][cH:19]2)[n:8][o:9]1.[CH3:37][S:38](=[O:39])(=[O:40])[N:41]1[CH2:42][CH2:43][NH:44][CH2:45][CH2:46]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([NH:10][C:11](=[O:12])[NH:13][c:14]2[cH:15][c:16]([S:20][c:21]3[n:22][cH:23][n:24][c:25]4[cH:26][c:27]([O:35][CH3:36])[c:28]([O:31][CH2:32][CH2:33][N:44]5[CH2:43][CH2:42][N:41]([S:38]([CH3:37])(=[O:39])=[O:40])[CH2:46][CH2:45]5)[cH:29][c:30]34)[cH:17][cH:18][cH:19]2)[n:8][o:9]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-6f732ab3f1114ab4ba3d94f5c7d1bcab
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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