1,4-Dioxane → 3-Butyryl-4-(3,5-difluoro-4-hydroxyphenylamino)-8-methoxyquinoline

HRID 814086Notes

Reaction equation

HRID 814086 reaction equation
[C:11]([CH2:12][CH2:13][CH3:14])(=[O:15])[c:16]1[cH:17][n:18][c:19]2[c:20]([O:27][CH3:28])[cH:21][cH:22][cH:23][c:24]2[c:25]1[Cl:26].[F:1][c:2]1[c:3]([OH:10])[c:4]([F:9])[cH:5][c:6]([NH2:8])[cH:7]1.[O:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1>>[F:1][c:2]1[c:3]([OH:10])[c:4]([F:9])[cH:5][c:6]([NH:8][c:25]2[c:16]([C:11]([CH2:12][CH2:13][CH3:14])=[O:15])[cH:17][n:18][c:19]3[c:20]([O:27][CH3:28])[cH:21][cH:22][cH:23][c:24]32)[cH:7]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 27787644-Amino-2,6-difluorophenolHCID 117775673-Butyryl-4-chloro-8-methoxyquinoline

Product 1

HCID 100447813-Butyryl-4-(3,5-difluoro-4-hydroxyphenylamino)-8-methoxyquinoline

Sources & evidence

ORD record
ord-92bdbeff28ad4a809a47580dab759d6d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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