Acetone → 4-Bromo-2,6-difluoroanisole

HRID 814144Notes

Reaction equation

[Br:3][c:4]1[cH:5][c:6]([F:12])[c:7]([OH:11])[c:8]([F:10])[cH:9]1.[CH3:19][C:20](=[O:21])[CH3:22].[CH3:1][I:2].[K+:13].[K+:14].[O-:15][C:16]([O-:17])=[O:18]>>[Br:3][c:4]1[cH:5][c:6]([F:12])[c:7]([O:11][CH3:16])[c:8]([F:10])[cH:9]1

Participants

Reactant 5

HCID 180Acetone

HCID 813Potassium Cation2×

HCID 6328Methyl iodide

HCID 19660Carbonate Ion

HCID 27362924-Bromo-2,6-difluorophenol

Product 1

HCID 27732874-Bromo-2,6-difluoroanisole

Sources & evidence

ORD record: ord-d02615d84c844ba88db1524e912e6228
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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