Potassium Carbonate → 7-isobutyl-5-methyl-3-(phenylamino)-2-(4-(pyrrolidin-1-ylmethyl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

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Reaction Steps

2-(4-(bromomethyl)benzyl)-7-isobutyl-5-methyl-3-(phenylamino)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (30 mg, 0.06 mmol), K2CO3 (16 mg, 0.12 mmol) and pyrrolidine (10 μL, 0.12 mmol) in THF is stirred at room temperature for 2 days. The mixture is then purified by HPLC to give final product as white powder. MS (ESI) m/z 487.3 [M+H]+.

Provenance & Evidence