3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 5-chloro-N-(4-(3,3-dimethyl-4-(methylamino)piperidin-1-yl)-2-methoxyphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine

HRID 814332Notes

Reaction equation

HRID 814332 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1.[NH2:18][c:19]1[c:20]([O:35][CH3:36])[cH:21][c:22]([N:25]2[CH2:26][C:27]([CH3:33])([CH3:34])[CH:28]([NH:31][CH3:32])[CH2:29][CH2:30]2)[cH:23][cH:24]1>>[c:2]1([NH:18][c:19]2[c:20]([O:35][CH3:36])[cH:21][c:22]([N:25]3[CH2:26][C:27]([CH3:33])([CH3:34])[CH:28]([NH:31][CH3:32])[CH2:29][CH2:30]3)[cH:23][cH:24]2)[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1

Participants

3

Reactant 2

HCID 566553763-(2,5-Dichloropyrimidin-4-yl)-1H-indoleHCID 580714481-(4-amino-3-methoxyphenyl)-N,3,3-trimethylpiperidin-4-amine

Product 1

HCID 580714265-chloro-N-(4-(3,3-dimethyl-4-(methylamino)piperidin-1-yl)-2-methoxyphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-36aa9a6e61c744f1a3fd4b81513ecb8d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…