Isopropyl 5-[acetyl-(3,5-bistrifluoromethylbenzyl)amino]-8-fluoro-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate → Isopropyl-5-[acetyl-(3,5-bistrifluoromethylbenzyl)amino]-7-bromo-8-fluoro-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate
Reaction equation
[CH:1]([CH3:2])([CH3:3])[O:4][C:5](=[O:6])[N:7]1[c:8]2[c:9]([cH:33][cH:34][c:35]([F:37])[cH:36]2)[CH:10]([N:14]([CH2:15][c:16]2[cH:17][c:18]([C:26]([F:27])([F:28])[F:29])[cH:19][c:20]([C:22]([F:23])([F:24])[F:25])[cH:21]2)[C:30]([CH3:31])=[O:32])[CH2:11][CH2:12][CH2:13]1.[CH:38]([O:39][C:40]([N:41]1[CH2:42][CH2:43][CH2:44][CH:45]([N:46]([C:47](=[O:48])[CH3:49])[CH2:50][c:51]2[cH:52][c:53]([C:54]([F:55])([F:56])[F:57])[cH:58][c:59]([C:60]([F:61])([F:62])[F:63])[cH:64]2)[c:65]2[cH:66][c:67]([Br:75])[c:68]([CH3:69])[cH:70][c:71]21)=[O:72])([CH3:73])[CH3:74]>>[CH:1]([CH3:2])([CH3:3])[O:4][C:5](=[O:6])[N:7]1[c:8]2[c:9]([cH:33][c:34]([Br:75])[c:35]([F:37])[cH:36]2)[CH:10]([N:14]([CH2:15][c:16]2[cH:17][c:18]([C:26]([F:27])([F:28])[F:29])[cH:19][c:20]([C:22]([F:23])([F:24])[F:25])[cH:21]2)[C:30]([CH3:31])=[O:32])[CH2:11][CH2:12][CH2:13]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-74de09f42af141cf80d27a42ab140685
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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