3-Fluorobenzenesulfonyl Chloride → N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-fluorobenzenesulfonamide

HRID 814461Notes

Reaction equation

HRID 814461 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:23])[c:20]([NH2:21])[cH:22]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1.[F:24][c:25]1[cH:26][c:27]([S:31](=[O:32])(=[O:33])[Cl:34])[cH:28][cH:29][cH:30]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:23])[c:20]([NH:21][S:31]([c:27]4[cH:26][c:25]([F:24])[cH:30][cH:29][cH:28]4)(=[O:32])=[O:33])[cH:22]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1

Participants

3

Reactant 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 579897855-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluoroaniline

Product 1

HCID 57989802N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-fluorobenzenesulfonamide

Sources & evidence

ORD record
ord-71437d42d4c94d87b4e37f028543cac2
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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