反应详情

2-(diethylamino)-ethyl chloride hydrochloride (1 g, 5.81 mmol) and benzylamine (1.3 ml, 11.62 mmol) were dissolved in t-butanol (40 ml), triethylamine (3.2 ml, 23.24 mmol) was added thereto, and the resulting solution was refluxed for 12 hours. The solution was cooled to room temperature, and distilled under a reduced pressure to remove the solvent. The resulting solid was removed by filtration under a reduced pressure, and the residual solution was extracted with ethylacetate The separated organic layer was washed with saturated sodium bicarbonate aqueous solution, dried over magnesium sulfate, filtered and distilled under a reduced pressure to obtain the title compound 560 mg (yield: 47%).

1. temperaturethe resulting solution was refluxed for 12 hours
2. distillationdistilled under a reduced pressure
3. customto remove the solvent
4. customThe resulting solid was removed by filtration under a reduced pressure
5. extractionthe residual solution was extracted with ethylacetate The separated organic layer
6. washwas washed with saturated sodium bicarbonate aqueous solution
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. distillationdistilled under a reduced pressure