Pyridine → HCID 44236425, compound

HRID 81471Notes

Reaction equation

HRID 81471 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[C:10]([CH:23]=[O:24])=[N:11][C:12]([C:15]2[CH:20]=[C:19]([NH2:21])[CH:18]=[CH:17][C:16]=2[CH3:22])=[CH:13][N:14]=1.[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[NH2:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([NH:21][C:5](=[O:7])[CH3:6])[CH:18]=[CH:17][C:16]=2[CH3:22])=[N:11][C:10]=1[C:23]([C:27]1[CH:26]=[N:25][CH:30]=[CH:29][CH:28]=1)=[O:24]

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 87523458HCID 87523458, compound

Product 1

HCID 44236425HCID 44236425, compound

Procedure

Acetic anhydride (19.7 ml, 0.21 mmol) is added to solution of Example 110 (48.5 mg, 0.15 mmol) in pyridine (1.5 ml), and the resulting solution is stirred at room temperature for 2 hours. The solvent is removed in vacuo and trituration with methanol and diethyl ether yields the title compound as a yellow solid; MS m/z 348 [M+H]+

Workup

  1. customThe solvent is removed in vacuo and trituration with methanol and diethyl ether

Sources & evidence

ORD record
ord-660b160e95a247d49348867e4ad67c8b
Source dataset
uspto-grants-2014_09
Patent number
US08846687B2

Reaction notes

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