HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-5-(morpholin-4-ylsulphonyl)benzeneboronic acid → 3-Amino-6-[2-methyl-5-(morpholine-4-sulfonyl)-phenyl]-pyrazine-2-carboxylic acid methoxy-methyl amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-5-(morpholin-4-ylsulphonyl)benzeneboronic acid | HCID 44119554 | — |
| Reactant | 3-Amino-6-(3,4-dichloro-phenyl)-pyrazine-2-carboxylic acid methoxy-methyl amide | HCID 86634542 | — |
| Product | 3-Amino-6-[2-methyl-5-(morpholine-4-sulfonyl)-phenyl]-pyrazine-2-carboxylic acid methoxy-methyl amide | HCID 86634543 | — |
Reaction Steps
This compound is prepared in an analogous manner to intermediate B substituting 3,4 dichlorophenyl boronic acid with 2-methyl-5-(N-morpholinylsulfonyl)phenyl boronic acid in step 2. The title compound is obtained as an off-white solid. [M+H]+ 422.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846687B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-9e5889ab11b94bd49176e246e6ed9dbc |
| Source note | uspto-grants-2014_09 |