Morpholine → 4-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

HRID 81484Notes

Reaction equation

HRID 81484 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)(=[O:10])=[O:9])[CH:7]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 866319035-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride

Product 1

HCID 686302274-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

5-Chloro-2-trifluoromethyl-benzenesulfonyl chloride (0.17 g, 0.62 mmol) is added to a solution of morphline (0.114 ml, 1.3 mol) in DCM (5 ml) and the resulting white suspension is stirred at room temperature overnight. The reaction mixture is diluted with DCM (5 ml), and washed with 0.1M HCl, dried (MgSO4) and concentrated in vacuo to yield the title compound. [M+H]+ 330.

Workup

  1. washwashed with 0.1M HCl
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-45708f4f8412433482efb34a2569e6cb
Source dataset
uspto-grants-2014_09
Patent number
US08846687B2

Reaction notes

Loading…