Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 814850Generated: October 25, 2026

Acetic Acid → 1-(9-((4-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-2,2,2-trifluoroethanone

https://huagongshe.com/reaction/814850

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantSodium ionHCID 923—
ReactantWaterHCID 962—
ReactantTrifluoroacetic acidHCID 6422—
ReactantN-methyl-2-pyrrolidoneHCID 13387—
ReactantTriacetoxyborohydrideHCID 2724942—
Reactant3-(2-(Tert-butyldimethylsilyloxy)ethyl)thiophene-2-carbaldehydeHCID 57988907—
Reactant2,2,2-Trifluoro-1-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)ethanoneHCID 57989026—
Reactant4-(2-(Tert-butyldimethylsilyloxy)ethyl)thiophene-2-carbaldehydeHCID 57989110—
Product1-(9-((4-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-2,2,2-trifluoroethanoneHCID 57989224—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-e8004444848f4d549439b12d980693fa
Source noteTest data from https://doi.org/10.1039/C8SC04228D