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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 815022Generated: October 30, 2026

Ethylene Glycol → 5-[1,3]dioxolan-2-yl-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-benzamide

https://huagongshe.com/reaction/815022

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthylene GlycolHCID 174—
ReactantBicarbonate IonHCID 769—
ReactantSodium ionHCID 923—
ReactantWaterHCID 962—
Reactantp-Toluenesulfonic acidHCID 6101—
ReactantTetrahydrofuranHCID 8028—
Reactant3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamideHCID 23132388—
Product5-[1,3]dioxolan-2-yl-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-benzamideHCID 59348028—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-e26803d02e124d449a4a71faea2623fc
Source noteTest data from https://doi.org/10.1039/C8SC04228D