2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N4-(4-trifluoromethoxyphenyl)-4-pyrimidineamine

HRID 815243Notes

Reaction equation

HRID 815243 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([Cl:8])[n:7]1.[F:10][C:11]([O:12][c:13]1[cH:14][cH:15][c:16]([NH2:17])[cH:18][cH:19]1)([F:20])[F:21]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([NH:17][c:16]2[cH:15][cH:14][c:13]([O:12][C:11]([F:10])([F:20])[F:21])[cH:19][cH:18]2)[n:7]1

Participants

3

Reactant 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 6008484-(Trifluoromethoxy)aniline

Product 1

HCID 220609412-chloro-5-fluoro-N4-(4-trifluoromethoxyphenyl)-4-pyrimidineamine

Sources & evidence

ORD record
ord-97ebd67db3e94078b6f4de73f38786c7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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